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Asmeninė informacija

Vardas: Saulius
Pavardė: Butenas
Saulius Butenas
Gimimo data: 1949-07-20
Elektroninis paštas:
Gyvenu: Jungtinėse Amerikos Valstijose

Išsilavinimas

  • 1985 m.Kauno politechnikos institutas - Mokslo daktaras (Chemija).
  • 1972 m.Kauno politechnikos institutas - Bakalauras (Chemija).
  • 1967 m.Rokiškio J.T. Vaižganto vidurinė mokykla. Įgytas vidurinis išsilavinimas.

Darbo patirtis

  • 1997 m. - dabarVermonto Universitetas (208 South Park Dr., Room 235A, Colchester, VT 05446, USA; tel.: +1-802-656-0350) - Profesorius. Kraujo kresejimo biochemija.
  • 1991 - 1997 m.Vermonto universitetas (JAV) - Doktorantas. Kraujo kresejimo biochemija.
  • 1989 - 1997 m.Biochemijos institutas (Vilnius) - Vyresnysis mokslinis bendradarbis. Organine sinteze.
  • 1986 - 1987 m."Fermentas" (Vilnius) - Mokslinis bendradarbis. Organine sinteze.
  • 1985 - 1986 m.Biochemijos institutas (Vilnius) - Jaunesnysis mokslinis bendradarbis. Organine sinteze.

Mokslinė informacija

Mokslinių tyrimų interesai: Kraujo kresejimo proceso dinamika.
Publikacijų sąrašas: Peržiūrėti

Kiti pasiekimai

  • Patentai:
  • 1. Butenas S, Juodvirsis A, Mikulskis P, Astrauskas V. 2-N-(cis-1,4-phthalimidocyclohexylcarbonyl)ami-no-2-deoxy-1,3,4,6-tetra-O-acetyl-D-glucopyranose possessing anti-inflammatory activity. USSR pat. 1058257 (1983).
  • 2. Juodvirsis A., Butenas S, Astrauskas V. 2-N-(w-phtalimidoalkanoyl)amino-2-deoxy-1,3,4,6-tetra-O-acetyl-D-glucopyrnoses possessing anti-inflammatory effect. USSR pat. 1139148 (1984).
  • 3. Butenas S, Lawson JH, Mann KG. 6-Peptidylamino-1-naphthalenesulfonamides useful as fluorogenic proteolytic enzyme substrates. USA patent 5,399,487 (1995).
  • 4. Butenas S, Mann KG. Peptidomimetics containing 6-peptidylamino-1-naphthalenesulfonamide moieties. USA patent 6,566,493 B1 (1998).
  • 5. Butenas S, Brummel KE, Mann KG. Compositions and Methods to Control Bleeding. USA patent 7,015,193 B2 (2006).
  • 6. Jenny RJ, Butenas S. Assay for Tissue Factor in a Sample. USA patent 7,604,932 B2 (2009).
  • 7. Butenas S, Mann KG. Methods of detecting of factor XIa and tissue factor. USA patent application 20100261198 (pending).
  • Grantu recenzentas:
  • 2009 – Ad Hoc member of the NIH review panel for Challenge grants
  • 2010 – Ad Hoc member of the NIH special panel: Member Conflict: Hematological Mechanisms
  • 2011 – Ad Hoc member of the NIH special panel: Tissue and Nanomaterials Technologies
  • 2011 – Ad Hoc member of the NIH Hemostasis and Thrombosis (HT) study section
  • 2011 – Ad Hoc member of the NIH special panel: Translational Research Centers in Thrombotic and Hemostatic Disorders (TRC-THD)
  • Redkolegiju narys:
  • 1. Thrombosis Research
  • 2. Journal of Biomedicine and Biotechnology
  • 3. The Open Journal of Hematology
  • 4. Journal of Thrombosis and Haemostasis
  • Rankrasciu recenzentas zurnalams:
  • 1. Blood
  • 2. Journal of Thrombosis and Haemostasis
  • 3. Thrombosis and Haemostasis
  • 4. Thrombosis Research
  • 5. Blood Coagulation and Fibrinolysis
  • 6. Haematologica
  • 7. Clinica Chimica Acta.
  • 8. BioDrugs.
  • 9. International Journal of Biological Macromolecules
  • 10. Coronary Artery Disease
  • 11. Innate Immunity
  • Pirmininkavimas konferencijose:
  • 1. Co-chair of a session at the 50th ASH Annual Meeting, San Francisco, CA, December 6-9, 2008.
  • 2. Co-chair of a session at the XXIII Congress of ISTH, Kyoto, Japan, July 23-28, 2011.
  • Kviesti pranesimai:
  • 1. Invited speaker at the 5th Novo Nordisk Symposium on the Treatment of Bleeding and Thrombotic Disorders, Copenhagen, Denmark, May 7-8, 1999.
  • 2. Invited speaker at the 1st Symposium on Hemostasis with Special Focus on factor VIIa & Tissue Factor, Chapel Hill, NC, April 4-6, 2002.
  • 3. Invited speaker at the 4th Symposium on Hemostasis with Special Focus on factor VIIa & Tissue Factor – Understanding the Molecular Mechanism, Chapel Hill, NC, April 3-5, 2008.
  • 4. Invited speaker at the 10th ETRO Advanced Teaching Course on Thrombosis, Krakow, Poland, October 12-16, 2009.
  • 5. Invited speaker at the 5th Symposium on Hemostasis with Special Focus on factor VIIa & Tissue Factor – from Cell Biology to Animal Models, Chapel Hill, NC, April 29-May 1, 2010.
  • 6. Invited speaker at the FDA workshop titled “Risk Mitigation Strategies to Address Potential Procoagulant Activity in Immune Globulin Intravenous (IGIV) Products. Rockville, MD, May 17-18, 2011.
  • Dalyvavimas konferencijose (2003-dabar):
  • 1.S Butenas*, KE Brummel, BA Bouchard, KG Mann. How factor VIIa works in hemophilia. Oral presentation OC217. XIX Congress of ISTH, Birmingham, UK, July 12-18, 2003.
  • 2.S Butenas*, T Orfeo, MT Gissel, KE Brummel, KG Mann. Systemic enzymatic activity in blood? Poster P1083. XIX Congress of ISTH, Birmingham, UK, July 12-18, 2003.
  • 3.KG Mann*, K Brummel, S Butenas. What is all that thrombin for? State of Art SOA02. XIX Congress of ISTH, Birmingham, UK, July 12-18, 2003.
  • 4.S Butenas*, KE Brummel, KG Mann. Active tissue factor in blood? Poster 143-III. 45th Annual ASH meeting, San Diego, CA, December 6-9, 2003.
  • 5.T Orfeo*, N Bruffato, ME Nesheim, H Xu, S Butenas, KG Mann. Factor V activation: an empirical and proteomic approaches. Poster PC193. IUBMB/ASBMB Meeting, June 12-16, 2004.
  • 6.SJ Ethier*, S Butenas, RJ Jenny. Fluorogenic assays for functional factor VIIa and tissue factor. Poster 894-I. 46th Annual ASH meeting, San Diego, CA, December 4-7, 2004.
  • 7.S Butenas*, T Orfeo, KE Brummel-Ziedins, KG Mann. Membrane-bound and soluble tissue factor – fuse and fire extinguisher. Oral presentation 123. 46th Annual ASH meeting, San Diego, CA, December 4-7, 2004.
  • 8.S Butenas*, MT Gissel, BA Bouchard, KE Brummel, B Parhami-Seren, KG Mann. Demystifying tissue factor. Poster 149-II. 46th Annual ASH meeting, San Diego, CA, December 4-7, 2004.
  • 9.S Butenas, B Parhami-Seren, MT Gissel, ED Gomperts, KG Mann. Quantitative evaluation of factor VIII in factor VIII products. Publication. 46th Annual ASH meeting, San Diego, CA, December 4-7, 2004.
  • 10.B Parhami-Seren*, S Butenas, B Bouchard, J Amblo, KG Mann. Quantitation of natural, recombinant, cell-surface and plasma tissue factor. Poster 142-II. 46th Annual ASH meeting, San Diego, CA, December 4-7, 2004.
  • 11.KE Brummel-Ziedins*, RF Branda, S Butenas, KG Mann. Hemophilia and the Dynamics of hemostasis. Oral presentation 321. 47th Annual ASH meeting, Atlanta, GA, December 10-13, 2005.
  • 12.B Parhami-Seren*, S Butenas, J Amblo, DN Fass, KG Mann. Quantitation of FVIII antigen in human plasma. Poster PO650. XX Congress of ISTH, Sydney, Australia, August 6-12, 2005.
  • 13.T Orfeo*, S Butenas, KE Brummel-Ziedins, KG Mann. What all that thrombin is for. Oral presentation OR373. XX Congress of ISTH, Sydney, Australia, August 6-12, 2005.
  • 14.S Butenas*, T Orfeo, KG Mann. Synergistic antagonists for hemophilia treatment. Oral presentation OR 210. XX Congress of ISTH, Sydney, Australia, August 6-12, 2005.
  • 15.S Butenas*, T Orfeo, KE Brummel-Ziedins, KG Mann. The influence of bivalirudin on tissue factor-initiated thrombin generation. Poster P1142. XX Congress of ISTH, Sydney, Australia, August 6-12, 2005.
  • 16.S Butenas*, B Parhami-Seren, MT Gissel, ED Gomperts, KG Mann. Activity and content of factor VIII in various factor VIII products. Poster P2028. XX Congress of ISTH, Sydney, Australia, August 6-12, 2005.
  • 17.S Butenas*, K Brummel-Ziedins, K Mann. Real human tissue factor. Poster 74.6. ASBMB Meeting 2006, San Francisco, CA, April 1-5, 2006.
  • 18.T Orfeo*, KE Brummel-Ziedins, S Butenas, KG Mann. Simulating blood coagulation: the contribution of α2-macroglobulin and α1-antitrypsin. Poster 80.7. ASBMB Meeting 2006, San Francisco, CA, April 1-5, 2006.
  • 19.S Butenas*, B Parhami-Seren, KG Mann. The influence of von Willebrand factor (vWF) on factor VIII(FVIII) activity in plasma. Poster P2547. XXI Congress of ISTH, Geneva, Switzerland, July 6-12, 2007.
  • 20.K Brummel-Ziedins, A Undas, T Orfeo, M Gissel, S Butenas*, K Zmudka, KG Mann. Thrombin generation profiles in patients with acute coronary syndrome and stable coronary artery disease: a computational analysis. Poster 1333. XXI Congress of ISTH, Geneva, Switzerland, July 6-12, 2007.
  • 21.S Butenas*, A Undas, MT Gissel, KG Mann. Factor XIa (FXIa) and tissue factor (TF) activity in plasma of patients with coronary artery disease (CAD). Poster 0233. XXI Congress of ISTH, Geneva, Switzerland, July 6-12, 2007.
  • 22.E Gomperts*, S Butenas, J Amblo, M Gissel, KG Mann. The influence of subject and product on factor VIII pharmacokinetics. Poster. XXVIII Congress of the WFH, Istanbul, Turkey, June 1-5, 2008.
  • 23.KG Mann, M Gissel, J Amblo, B Parhami-Seren, S Butenas*. Quantitation of factor VIII: activity, antibodies and vWF. Oral presentation. XXVIII Congress of the WFH, Istanbul, Turkey, June 1-5, 2008.
  • 24.S Butenas*, B Parhami-Seren, M Gissel, J Amblo, K Brummel-Ziedins, KG Mann. The nature of LPS-stimulated monocyte tissue factor activity. Oral presentation. 50th ASH Annual Meeting, San Francisco, CA, December 6-9, 2008.
  • 25.J Krudysz-Amblo*, B Parhami-Seren, S Butenas, K Brummel-Ziedins, ED Gomperts, GE Rivard, KG Mann. Quantitation of non-inhibitory anti-factor VIII antibodies in human plasma. Poster, 50th ASH Annual Meeting, San Francisco, CA, December 6-9, 2008.
  • 26.S Butenas, A Undas, M.Gissel, KG Mann. Factor XIa and tissue factor in patients with cardiovascular and inflammatory diseases. XXII Congress of ISTH, Boston, USA, July 11-16, 2009.
  • 27.S Butenas, B Parhami-Seren, A Undas, KG Mann. Reevaluation of “normal” factor VIII concentration in plasma. XXII Congress of ISTH, Boston, USA, July 11-16, 2009.
  • 28.T. Orfeo, K Brummel-Ziedins, M Gissel, S Butenas, KG Mann. Computational modeling of warfarin therapy. XXII Congress of ISTH, Boston, USA, July 11-16, 2009.
  • 29.Campbell JE, Whelihan MF, Brummel-Ziedins KE, Orfeo T, Krudysz-Amblo J, Butenas S, Mann KG. Endothelial cell regulation of blood coagulation: a model for venous stasis. XXII Congress of ISTH, Boston, USA, July 11-16, 2009.
  • 30.Krudysz-Amblo J, Mann KG, Butenas S. The influence of glycosylation on tissue factor activity. XXII Congress of ISTH, Boston, USA, July 11-16, 2009.
  • 31.Brummel-Ziedins KE, Orfeo T, Rosendaal FR, Undas A, Rivard GE, Butenas S, Mann KG. Empirical and theoretical phenotypic discrimination. XXII Congress of ISTH, Boston, USA, July 11-16, 2009.
  • 32.Jennings II ME, Krudusz-Amblo J, Butenas S, Mann KG, Matthews DE. Glycoprotein profiling simplified using an ion trap mass spectrometer. 58th ASMS Conference on Mass Spectrometry, Salt Lake City, UT, May 23-27, 2010.
  • 33.Butenas S, Whelihan MF, Brummel-Ziedins K, Rivard GE, Mann KG. Inhibitor of activated protein C as an adjuvant for hemophilia treatment. XXIX International Congress of the WFH, Buenos Aires, Argentina, July 10-14, 2010.
  • 34.Jennings II ME, Krudusz-Amblo J, Mann KG, Butenas S, Matthews DE. Total retention liquid chromatography for maximum protein sequence coverage by mass spectrometry. 59th ASMS Conference on Mass Spectrometry, Denver, CO, June 5-9, 2011.
  • 35.Krudysz-Amblo J, Jennings II ME, Matthews DE, Mann KG, Butenas S. Posttranslational modifications and activity of natural human tissue factor. XXIII Congress of ISTH, Kyoto, Japan, July 23-28, 2011.
  • 36.Wulfkuhle K, Butenas S, Bernstein I, Brummel-Ziedins K. Tissue factor dependent and independent thrombin generation across pregnancy. XXIII Congress of ISTH, Kyoto, Japan, July 23-28, 2011.
  • 37.Butenas S, Gissel M, Orfeo T, Mann KG. Tissue factor pathway inhibitor aptamer as a potential drug for hemophilia treatment. XXIII Congress of ISTH, Kyoto, Japan, July 23-28, 2011.
  • 38.Krudysz-Amblo J, Jennings II ME, Knight T, Matthews DE, Mann KG, Butenas S. Allosteric Cysteine Oxidation Does Not Play a Role in Tissue Factor Decryption. 53th ASH Annual Meeting, San Diego, CA, December 10-13, 2011.
  • 39.Orfeo T, Gissel M, Whelihan M, Butenas S, Mann K. Factor XI activation in tissue factorinitiated blood coagulation. 53th ASH Annual Meeting, San Diego, CA, December 10-13, 2011.

Gyvenimo aprašymas